- Test Name
- Phospholipase A2 Receptor Antibody (Serum)
- Aliases
- Antiphospholipase A2 Receptor Autoantibodies; Anti-PLA2R; PLA2R
- Provincial Mnemonic
- PLA2RAB
- LOINC Test Code
- 73737-9
- Description and Primary Use
- The phospholipase A2 receptor (PLA2R) is a type I transmembrane glycoprotein related to the Ctype animal lectin family that includes the mannose receptor. Being both a transmembrane glycoprotein receptor and a soluble receptor, PLA2R regulates a variety of biological responses through binding phospholipase A2. PLA2R’s function includes the induction of cell proliferation, cell migration, and lipid mediator production. Anti-PLA2R is an autoimmune diagnostic test that detects autoantibodies against phospholipase A2 receptors (PLA2R). The results are useful in the diagnosis of idiopathic membranous nephropathy. When this test is negative, testing for antibodies to thrombospondin should be considered in the diagnosis of primary membranous nephropathy (MGN, pMGN) or idiopathic membranous nephropathy (IMN).
- Reorder interval
- TAT
- 3 Weeks
- Test Cost
- $158
- Tier
- 3 - Special Authorization Required (See Required Consultation)
- Ordering Requirements (Restrictions / Conditions)
A LTSA form must be completed with the test name clearly identified and one of the above clearly indicated as reason for the test request.
- Required Consultations
- Nephrologists
- Algorithms and Guidelines
- Special Patient Preparation
- Special Collection / Transport / Processing Requirements
Separate and refrigerate serum immediately, Send on dry ice. If serum and CSF are to be sent out together, both samples can be sent at 4 C with ice packs.
- Criteria for Rejection
Grossly Hemolysed.
- Laboratory Service Area
- Clinical Chemistry
- Performing Laboratory / Site
- MitogenDx - Calgary - AB - Canada
- Last Updated
- 22-Jan-24