- Test Name
- Thyroid Peroxidase Antibody
- Aliases
- Anti-TPO, ATPO
- Provincial Mnemonic
- THYPAB
- LOINC Test Code
- 8099-4
- Description and Primary Use
- Unlike autoantibodies to thyroglobulin (anti-Tg), autoantibodies to TPO are potentially deleterious and may have a pathogenic role in (destructive) autoimmine thyroid disease. Anti-TPO antibodies are found often in conjunction with anti-Tg in the majority of cases of Hashimoto's thyroiditis, Primary Myxedema, and Graves' disease. The relationship of autoimmine thyroid disease to pregnancy has been the subject of considerable interest with the recognition of the postpartum thyroid disease syndromes. Anti-TPO antibodies are demonstrable in most cases of postpartum thyroiditis and it has been found that the presence of autoantibody in early pregnancy was associated with a high risk of asymptomatic postpartum hypothyroidism. It is common to find anti-TPO antibodies in the absence of autoantibodies to thyroglobulin, particularly in patients with small goitres and up to 64% of cases of autoimmune hypothyroidism have been reported to be associated with anti-TPO antibodies alone. In addition, anti-TPO antibodies are frequently found in patients with other autoimmune diseases such as Rheumatoid Arthritis, Addison's Disease and Type I Diabetes. They are also detectable at low levels in up to 20% of asymptomatic individuals, particularly the elderly and more often in women than in men, although the clinical significance of these autoantibodies is unclear.
- Reorder interval
- 90 Days
- TAT
- ≤3 Days
- Test Cost
- Not Available
- Tier
- 1 - General Availability
- Ordering Requirements (Restrictions / Conditions)
No Restrictions
- Required Consultations
- None
- Algorithms and Guidelines
None
- Special Patient Preparation
None
- Special Collection / Transport / Processing Requirements
No special requirement
- Criteria for Rejection
Based on specimen condition and stability
- Laboratory Service Area
- Clinical Chemistry
- Performing Laboratory / Site
- Category 4 Laboratory (HSC only)
- Last Updated
- 18-Sep-19